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neurofibrillary tangles
neurofibrillary tangles Neurofibrillary tangles are abnormal clumps inside brain cells made of tightly packed twisted filaments involving neurofilaments, microtubule-related proteins, actin, and ubiquitins.
Neurofibrillary tangles are abnormal clumps inside brain cells made of tightly packed twisted filaments involving neurofilaments, microtubule-related proteins, actin, and ubiquitins. They are a major biological feature of Alzheimer disease and, after death, higher numbers of tangles are associated with more severe dementia during life.