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acute tolerance

acute tolerance Acute tolerance is a rapid, within-session reduction in a drug’s intoxicating effect as the nervous system adjusts while the drug is still present.

Acute tolerance is a rapid, within-session reduction in a drug’s intoxicating effect as the nervous system adjusts while the drug is still present. With alcohol, it means impairment is greater early in a drinking episode than later at a similar blood alcohol level, reflecting adaptation rather than faster metabolism.