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Werdnig–Hoffmann disease
Werdnig–Hoffmann disease Werdnig–Hoffmann disease is the most severe form of spinal muscular atrophy.
Werdnig–Hoffmann disease is the most severe form of spinal muscular atrophy. It begins in the first year of life and causes muscle weakness, low muscle tone, and failure to develop normal movement; loss of motor neurons especially affects breathing, and many affected children die before age two, often from pneumonia.