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senescence

senescence Senescence is a cellular aging state controlled mainly by the p16INK4a/Rb and p53/p21 pathways.

Senescence is a cellular aging state controlled mainly by the p16INK4a/Rb and p53/p21 pathways. It can be triggered by DNA damage responses or by epigenetic changes that alter gene expression.

Sources

Drafting source: Liu Dongliang; Liu Yudong; Wu Tianding; Hu Jianzhong. UTX/Top2β axis mediated spinal cord microvascular endothelial cells senescence exacerbates spinal cord injury. 2025; DOI 10.1371/journal.pone.0338326; article XML SHA-256 843ca0a1be833ca6626ef077c70b8705226eaf539764a22280e2cf06529869d6. “UTX/Top2β axis mediated spinal cord microvascular endothelial cells senescence exacerbates spinal cord injury” (10.1371/journal.pone.0338326).
CC-BY-4.0 · Definition uses new wording; original source retains its stated licence. · Source snapshot SHA-256: 843ca0a1be833ca6626ef077c70b8705226eaf539764a22280e2cf06529869d6

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PsychTerms (psychterms.org), CC BY 4.0, version 1. “senescence.” Development preview.

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senescence

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Sources

Cite this entry