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primary factor

primary factor In this historical usage, a primary factor is the earliest underlying change thought to start mental disorder: a disturbance in the normal relation between nutrition and function of brain tissue.

In this historical usage, a primary factor is the earliest underlying change thought to start mental disorder: a disturbance in the normal relation between nutrition and function of brain tissue. It was described as preceding clearer illness states such as mania or melancholia and as showing itself first in vague early symptoms like restlessness, irritability, and physical decline.