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amitriptyline

amitriptyline Amitriptyline is a tricyclic antidepressant with sedating and anticholinergic effects.

Amitriptyline is a tricyclic antidepressant with sedating and anticholinergic effects. It appears to work by reducing the reuptake of norepinephrine and serotonin at nerve endings, which increases their activity, and it also seems to block some cholinergic and alpha-1 adrenergic responses.

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Sources

Drafting source: U.S. National Library of Medicine. Medical Subject Headings (MeSH), 2026 descriptor edition. “Amitriptyline” (D000639).
public-domain-US-government · Definition uses new wording; original source retains its stated licence. · Source snapshot SHA-256: f4339837e5ce728d59229737271179cfc45f7c4c2318205c617937116f54440b

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PsychTerms (psychterms.org), CC BY 4.0, version 1. “amitriptyline.” Development preview.

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